In 1780s London Dr. Thomas Silkstone, a native of Philadelpia, has been studying anatomy for seven years and is gaining a reputation for himself as a skilled and dedicated anatomist. Thomas would be more than willing to continue to pursue his studies purely to gain more knowledge of the human body but when Lady Lydia Farrell requests his aid in discovering whether her brother, Earl Crick, was poisoned he finds himself drawn out of his laboratory and into a court room. Lady Farrell is desperate to find the truth as the local rumor mill has cast her husband as the murderer.